Bioinformatics Open Source Conference 2013, day 1 morning: Cameron Neylon and Open Science

I’m in Berlin at the 2013 Bioinformatics Open Source Conference. The conference focuses on tools and approaches to openly developing research software to support scientific research. These are my notes from the morning 1 session focused on Open Science.

Open Science

Network ready research: The role of open source and open thinking

Cameron Neylon

Cameron keynotes the first day of the conference, discussing the value of open science. He begins with a historical perspective of a connected world: first internet, telegraphs, stagecoaches all the way to social networks, twitter and GitHub. A nice overview of the human desire to connect. As the probability of connectivity rises, individual clusters of connected groups can reach a critical sudden point of large-scale connectivity. A nice scientific example is Tim Gowers PolyMath work to solve difficult mathematical problems, coordinated through his blog and facilitated by internet connectivity. Instructive to look at examples of successful large scale open science projects, especially in terms of organization and leadership.

Successful science projects exploit the order-disorder transition that occurs when the right people get together. By being open, you increase the probability that your research work will reach this critical threshold for discovery. Some critical requirements: document so people can use it, test so we can be sure it works, package so it’s easy to use.

What does it mean to be open? First idea: your work has value that can help people in a way you never initially imagined. Probability of helping someone is the interest divided by the usability times the number of people you can reach. Second idea: someone can help me in a way you never expected. Probability of getting help same: interest, usability/friction and number of people. Goal of being open: minimize friction by making it easier to contribute and connect.

Challenge: how do we best make our work available with limited time? Good example is how useful are VMs: are they criitical for recomputation or do they create black boxes that are hard to reuse. Both are useful but work for different audiences: users versus developers. Since we want to enable unexpected improvements it’s not clear which should be your priority with limited time and money. Goal is to make both part of your general work so they don’t require extra work.

How can we build systems that allow sharing as the natural by-product of scientific work? Brutal reminder that you’re not going to get a Nobel prize for building infrastructure. Can we improve the incentives system? One attempt to hack the system: the Open Research Computation journal, which has high standards for inclusion: 100% test coverage, easy to run and reproduce. Difficult to get papers because the burden was too high.

Goal: build community architecture and foundations that become part of our day to day life. This makes openness part of the default. Where are the opportunities to build new connectivity in ways that make real change? An unsolved open question for discussion.

Open Science Data Framework: A Cloud enabled system to store, access, and analyze scientific data

Anup Mahurkar

The Open Science Data Framework comes from the NIH human microbiome project. Needed to manage large connections of data sets and associate metadata. Developed a general language agnostic collaborative framework. It’s a specialized document database with a RESTful API on top, and provides versioning and history. Under the covers, stores JSON blobs in CouchDB, using ElasticSearch to provide rapid full text search. Keep ElasticSearch indexes in sync on updates to CouchDB. Provides a web based interface to build queries and custom editor to update records. Future places include replicated servers and Cloud/AWS images.

myExperiment Research Objects: Beyond Workflows and Packs

Stian Soiland-Reyes

Stian describes work on developing, maintaining and sharing scientific work. Uses Taverna, MyExperiment and Workflow4Ever to provide a fully shared environment with Research Object. These objects bundle everything involved in a scientific experiment: data, methods, provenance and people. Creates a sharable, evolvable and contributable object that can be cited via ROI. The Research Object is a data model that contains everything needed to rerun and reproduce it. Major focus on provenance: where did data come from, how did it change, who did the work, when did it happen. Uses the PROV w3c standard for representation, and built a w3c community to discuss and improve research objects. There are PROV tools available for Python and Java.

Empowering Cancer Research Through Open Development

Juli Klemm

The National Cancer Informatics Program provides support for community developed software. Looking to support sustainable, rapidly evolving, open work. The Open Development initiative exactly designed to support and nurture open science work. Uses simple BSD licenses and hosts code on GitHub. Moving hundreds of tools over to this model and need custom migrations for every project. Old SVN repositories required a ton of cleanup. The next step is to establish communities around this code, which is diverse and attracts different groups of researchers. Hold hackathon events for specific projects.

DNAdigest – a not-for-profit organisation to promote and enable open-access sharing of genomics data

Fiona Nielsen

DNAdigest is an organization to share data associated with next-generation sequencing, with a special focus on trying to help with human health and rare diseases. Researchers have access to samples they are working on, but remain siloed in individual research groups. Comparison to other groups is crucial, but no methods/approaches for accessing and sharing all of this generated data. To handle security/privacy concerns, goal is to share summarized data instead of individual genomes. DNAdigest’s goal is to aggregate data and provide APIs to access the summarized, open information.

Jug: Reproducible Research in Python

Luis Pedro Coelho

Jug provides a framework to build parallelized processing pipelines in Python. Provides a decorator on each function that handles distribution, parallelization and memoization. Nice documentation is available.

OpenLabFramework: A Next-Generation Open-Source Laboratory Information Management System for Efficient Sample Tracking

Markus List

OpenLabFramework provides a Laboratory Information Management System to move away from spreadsheets. Handles vector clone and cell-line recombinant systems for which there is not a lot of support. Written with Grails and built for extension of parts. Has nice documentation and deployment.

Ten Simple Rules for the Open Development of Scientific Software

Andreas Prlic, Jim Proctor, Hilmar Lapp

This is a discussion period around ideas presented in the published paper on Ten Simple Rules for the Open Development of Scientific Software. Andreas, Jim and Hilmar pick their favorite rules to start off the discussion. Be simple: minimize time sinks by automating good practice with testing and continuous integration frameworks. Hilmar talks about re-using and extending other code. The difficult thing is that the recognition system does not reward this well since it assumes a single leader/team for every probject. Promotes ImpactStory which provides alternative metrics around open source contributions. The Open Source Report Card also provides a nice interface around GitHub for summarizing contributions. Good discussion around how to measure metrics of usage of your project: need to be able to measure impact of your software.


3 thoughts on “Bioinformatics Open Source Conference 2013, day 1 morning: Cameron Neylon and Open Science

  1. Pingback: Bioinformatics Open Source Conference 2013, day 1 afternoon: visualization and project updates | Small Change Bioinformatics

  2. Pingback: Bioinformatics Open Source Conference 2013, day 2 morning: Sean Eddy and Software Interoperability | Small Change Bioinformatics

  3. Pingback: Bioinformatics Open Source Conference 2013, day 2 afternoon: cloud computing, translational genomics and funding | Small Change Bioinformatics

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